ATM-dependent CHK2 Activation Induced by Anticancer Agent, Irofulven
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چکیده
منابع مشابه
ATM and Chk2-dependent phosphorylation of MDMX contribute to p53 activation after DNA damage.
The p53 tumor suppressor is activated after DNA damage to maintain genomic stability and prevent transformation. Rapid activation of p53 by ionizing radiation is dependent on signaling by the ATM kinase. MDM2 and MDMX are important p53 regulators and logical targets for stress signals. We found that DNA damage induces ATM-dependent phosphorylation and degradation of MDMX. Phosphorylated MDMX is...
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Drugs. The Drug Synthesis and Chemistry Branch, Division of Cancer Treatment, NCI, National Institutes of Health (NIH), provided camptothecin (CPT) and flavopiridol (FLV). Aphidicolin (APD), 5,6-dichlorobenzimidazole 1-β-D-ribofuranoside (DRB), and α-amanitin were obtained from Sigma (St Louis, MO). Hydrogen peroxide (H2O2) was obtained from Fisher Scientific (Pittsburgh, PA). Iodouridine (IdU)...
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Tumor suppressor gene BRCA1 is frequently mutated in familial breast and ovarian cancer. BRCA1 plays pivotal roles in maintaining genomic stability by interacting with numerous proteins in cell cycle control and DNA repair. Irofulven (6-hydroxymethylacylfulvene, HMAF, MGI 114, NSC 683863) is one of a new class of anticancer agents that are analogs of mushroom-derived illudin toxins. Preclinical...
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The Fanconi anemia-BRCA pathway of genes are frequently mutated or epigenetically repressed in human cancer. The proteins of this pathway play pivotal roles in DNA damage signaling and repair. Irofulven is one of a new class of anticancer agents that are analogues of mushroom-derived illudin toxins. Preclinical studies and clinical trials have shown that irofulven is effective against several t...
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The ataxia telangiectasia mutated serine/threonine kinase (ATM)/checkpoint kinase 2 (CHEK2, best known as CHK2) and the ATM and Rad3-related serine/threonine kinase (ATR)/CHEK1 (best known as CHK1) cascades are the 2 major signaling pathways driving the DNA damage response (DDR), a network of processes crucial for the preservation of genomic stability that act as a barrier against tumorigenesis...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2004
ISSN: 0021-9258
DOI: 10.1074/jbc.m400015200